- About
- People
- Faculty
- Tim Audas
- Christopher Beh
- Lorena Braid
- Fiona S.L. Brinkman
- Mark Brockman
- Jonathan Choy
- Lisa Craig
- Sharon Gorski
- Nicholas Harden
- Nancy Hawkins
- Robert Holt
- William Hsiao
- Valentin Jaumouillé
- Lisa Julian
- Dustin King
- Irina Kovalyova
- Mani Larijani
- Amy Lee
- Michel Leroux
- Ryan Morin
- Ingrid Northwood
- Mark Paetzel
- Lynne Quarmby
- Dheva Setiaputra
- Michael Silverman
- Sophie Sneddon
- Glen Tibbits
- Peter Unrau
- Esther Verheyen
- Stephanie Vlachos
- David Vocadlo
- Edgar Young
- Emeritus Faculty
- Associate Members
- Adjunct Faculty
- Research Personnel
- Graduate & Postdocs
- Staff
- Department Committees
- Faculty
- Undergraduate
- Prospective Students
- Admission & Transferring
- Degree Programs
- MBB Co-op Program
- Careers in Molecular Biology and Biochemistry
- Scholarships & Funding
- Student Stories
- Contact Us
- Current Students
- Advising
- Courses
- Degree Programs
- MBB Co-op Program
- Research Opportunities
- Scholarship & Funding
- Student Resources
- Prospective Students
- Graduate
- Graduate Studies Overview and Timeline
- Prospective Students
- Current Students
- Manage Your Program
- Degree Requirements
- Courses
- Course Descriptions
- Course Offerings
- Spring (1251)
- Summer (1254)
- Spring (1241)
- Summer (1244)
- Fall (1247)
- Spring (1231)
- Summer (1234)
- Fall (1237)
- Spring (1221)
- Summer (1224)
- Fall (1227)
- Fall (1217)
- Summer (1214)
- Spring (1211)
- Fall (1207)
- Summer (1204)
- Spring (1201)
- Fall (1197)
- Summer (1194)
- Spring (1191)
- Fall (1187)
- Summer (1184)
- Spring (1181)
- Fall (1177)
- Summer (1174)
- Spring (1171)
- Fall (1167)
- Summer (1164)
- Spring (1161)
- Fall (1157)
- Spring (1151)
- Graduate Student Stipend & Awards
- Forms And Resources
- Events
- Graduate Student Caucus
- Research
- Research Labs
- Audas Lab
- Beh Lab
- Braid lab
- Brinkman Lab
- Brockman Lab
- Chen Lab
- Choy Lab
- Craig Lab
- Gorski Lab
- Harden Lab
- Hawkins Lab
- Holt Lab
- Hsiao Lab
- Jaumouillé Lab
- Julian Lab
- King Lab
- Larijani Lab
- Lee Lab
- Leroux Lab
- Morin Lab
- Paetzel Lab
- Pio Lab
- Quarmby Lab
- Sen Lab
- Setiaputra Lab
- Silverman Lab
- Thewalt Lab
- Tibbits Lab
- Unrau Lab
- Verheyen Lab
- Vocadlo Lab
- Young Lab
- Bioinformatics & Genomics
- Cells & Disease
- Infection & Immunity
- Macromolecular Biochemistry
- Undergraduate Research Opportunities
- Postdoctoral Research Opportunities
- C2D2 Centre for Cell Biology, Development, and Disease
- Omics Data Science Initiative
- Recent Publications
- Research Labs
- Resources
- News & Events
- Support MBB
- Faculty + Staff Portal
Chen Lab
My laboratory is interested in developing bioinformatics programs and genomics (and molecular) tools for understanding genome architecture and expression.
In particular, we are interested in characterizing gene structures, transcription factors and regulatory elements, sequence and structural variations, and, more importantly, regulatory mechanisms. Ultimately, we are interested in understanding how genome sequences and their organization (including various modifications) direct development and biological functions. Currently, we primarily use the nematode Caenorhabditis elegans as a model system. Bioinformatics programs and genomics tools, however, are generally readily applicable in all organisms, ranging from bacteria to humans. Current research projects fall into two major categories: (1) Identification and characterization of novel genes, synteny blocks, functional elements, genome variations and genome rearrangements; (2) Transcriptional regulation of genes and gene batteries.
For more details, visit our research lab website.
Selected Publications
- Song H, Chen Y, Liu F, Chen N (2021) Large Differences in the Haptophyte Phaeocystis globosa Mitochondrial Genomes Driven by Repeat Amplifications. Front. Microbiol. 12:676447. doi: 10.3389/fmicb.2021.676447.
- Zongmei C, Qing X, Kate G, Shuya L, Chen N (2021) Metabarcoding analysis of harmful algal bloomspecies in the Changjiang Estuary, China. Science of the Total Environment 782 (2021) 146823. doi: org/10.1016/j.scitotenv.2021.146823.
- Liu S, Gibson K, Cui Z, Chen Y, Sun X, Chen N (2020). Harmful Algae 92 (2020) 101772. doi: org/10.1016/j.hal.2020.101772.
- Gong G, Dan C, Xiao S, Guo W, Huang P, Xiong Y, Wu J, He Y, Zhang J, Li X, Chen N, Gui JF, Mei J. Chromosomal-level assembly of yellow catfish genome using third-generation DNA sequencing and Hi-C analysis. Gigascience. 2018 Nov 1;7(11). doi: 10.1093/gigascience/giy120.
- Xu S, Xiao S, Zhu S, Zeng X, Luo J, Liu J, Gao T, Chen N. A. draft genome assembly of the Chinese sillago (Sillago sinica), the first reference genome for Sillaginidae fishes. Gigascience. 2018 Sep 1;7(9). doi: 10.1093/gigascience/giy108.
- Qin Z, Johnsen R, Yu S, Chu JS, Baillie DL, Chen N. Genomic Identification and Functional Characterization of Essential Genes in Caenorhabditis elegans. G3 (Bethesda). 2018 Mar 2;8(3):981-997. doi: 10.1534/g3.117.300338.