- About
- People
- Faculty
- Tim Audas
- Christopher Beh
- Lorena Braid
- Fiona S.L. Brinkman
- Mark Brockman
- Jonathan Choy
- Lisa Craig
- Sharon Gorski
- Nicholas Harden
- Nancy Hawkins
- Robert Holt
- William Hsiao
- Valentin Jaumouillé
- Lisa Julian
- Dustin King
- Irina Kovalyova
- Mani Larijani
- Amy Lee
- Michel Leroux
- Ryan Morin
- Ingrid Northwood
- Mark Paetzel
- Frederic Pio
- Lynne Quarmby
- Dheva Setiaputra
- Michael Silverman
- Sophie Sneddon
- Glen Tibbits
- Peter Unrau
- Esther Verheyen
- Stephanie Vlachos
- David Vocadlo
- Edgar Young
- Emeritus Faculty
- Associate Members
- Adjunct Faculty
- Research Personnel
- Graduate & Postdocs
- Staff
- Department Committees
- Faculty
- Undergraduate
- Prospective Students
- Admission & Transferring
- Degree Programs
- MBB Co-op Program
- Careers in Molecular Biology and Biochemistry
- Scholarships & Funding
- Student Stories
- Contact Us
- Current Students
- Advising
- Courses
- Degree Programs
- MBB Co-op Program
- Research Opportunities
- Scholarship & Funding
- Student Resources
- Prospective Students
- Graduate
- Prospective Students
- Current Students
- Manage Your Program
- Degree Requirements
- Courses
- Course Descriptions
- Course Offerings
- Spring (1251)
- Spring (1241)
- Summer (1244)
- Fall (1247)
- Spring (1231)
- Summer (1234)
- Fall (1237)
- Spring (1221)
- Summer (1224)
- Fall (1227)
- Fall (1217)
- Summer (1214)
- Spring (1211)
- Fall (1207)
- Summer (1204)
- Spring (1201)
- Fall (1197)
- Summer (1194)
- Spring (1191)
- Fall (1187)
- Summer (1184)
- Spring (1181)
- Fall (1177)
- Summer (1174)
- Spring (1171)
- Fall (1167)
- Summer (1164)
- Spring (1161)
- Fall (1157)
- Summer (1154)
- Spring (1151)
- Funding and Awards
- Forms And Resources
- Events
- Graduate Student Caucus
- Research
- Research Labs
- Audas Lab
- Beh Lab
- Braid lab
- Brinkman Lab
- Brockman Lab
- Chen Lab
- Choy Lab
- Craig Lab
- Gorski Lab
- Harden Lab
- Hawkins Lab
- Holt Lab
- Hsiao Lab
- Jaumouillé Lab
- King Lab
- Larijani Lab
- Lee Lab
- Leroux Lab
- Morin Lab
- Paetzel Lab
- Pio Lab
- Quarmby Lab
- Sen Lab
- Setiaputra Lab
- Silverman Lab
- Thewalt Lab
- Tibbits Lab
- Unrau Lab
- Verheyen Lab
- Vocadlo Lab
- Young Lab
- Bioinformatics & Genomics
- Cells & Disease
- Infection & Immunity
- Macromolecular Biochemistry
- Undergraduate Research Opportunities
- C2D2 Centre for Cell Biology, Development, and Disease
- Omics Data Science Initiative
- Recent Publications
- Research Labs
- Resources
- News & Events
- Seminars
- MBB Calendar
- Colloquia
- Honours & Awards
- News Archives
- 2024
- Fiona Brinkman Recognized with Excellence in Science Public Engagement, Communication & Outreach Award
- Lionel Pereira receives Faculty of Science Graduate Student Excellence in Teaching Award
- Scientists develop tool to predict sepsis in apparently healthy newborns
- Dr. Lynne Quarmby, cool new discoveries about Watermelon Snow
- Dr. Valentin Jaumouillé and Dr. Amy Lee, Molecular Biology and Biochemistry researchers receive Michael Smith Health Research BC Scholar awards
- Dr. Ryan Morin has been honored with the Bernard and Francine Dorval Prize from the Canadian Cancer Society
- Verheyen Lab breakthrough identifies gene that may reverse Parkinson’s disease
- MBB researchers awarded $2 million in funding from the Canadian Institutes of Health Research
- Dr. Glen Tibbits honoured as Distinguished SFU Professor
- Reflecting on barriers and progress towards equity in science
- Royal Society of Canada bestows Dr. Vocadlo with country’s highest academic honour
- Decoding the genome to predict the clinical course of lymphomas
- 2023 Award for Excellence in Supervision: Esther Verheyen
- In a recent Nature Communications paper, the Audas lab demonstrates that proteins can act as microscopic thermometers to sense and respond to changing environmental conditions
- 2023
- Dr. Dustin King speaks to Molecular Cell about sustainability and molecular biology
- Science Advances paper by new MBB PhD, Casey Engstrom and Professor Lynne Quarmby uses satellites to study the impact of Watermelon Snow on glacier loss in North America
- Dr. Sathiyaseelan and team explore the expression and therapeutic target potential of cysteine protease ATG4 in pancreatic cancer
- 2022
- 2021
- 2020
- 2019
- 2018
- 2017
- 2016
- 2015
- 2024
- Science Rendezvous
- MBB Halloween
- Support MBB
- Faculty + Staff Portal
Craig Lab
The bacterial Type IV pilus apparatus is a remarkable molecular machine that rapidly assembles and disassembles protein polymers to perform diverse functions related to microbial pathogenesis.
Work in the Craig lab focuses on Type IV pili, hairlike filaments on the surfaces of many bacterial pathogens, such as Vibrio cholerae, pathogenic Escherichia coli and Neisseria spp. Type IV pili are dynamic filaments that rapidly polymerize and depolymerize in order to perform diverse functions critical to bacterial virulence, including twitching motility, host cell adhesion, microcolony formation, DNA uptake and protein secretion. We use structural biology, bacterial genetics and computational approaches to explore pilus structure, function and assembly with the goal of targeting and even expoliting these molecular machines for antimicrobial therapies.
Selected Publications
- M. Nguyen*, T.-H. Wu*, K.J. Danielson*, N.M. Khan*, Z. Zhang* and L. Craig (2023). Mechanism of secretion of TcpF by the Vibrio cholerae toxin coregulated pilus. Proc Nat’l Acad Sci, DOI: 10.1073/pnas.2212664120, PMID 27040409, 2023. https://www.pnas.org/doi/10.1073/pnas.2212664120
- F. Wang, L. Craig, X. Liu, C. Rensing & E. H. Egelman (2023). Microbial nanowires: type IV pili or cytochrome filaments? (2023) Trends Microbiol 31, 384-392, PMID: 36446702. https://pubmed.ncbi.nlm.nih.gov/36446702/
- R.R. Sonani, J. C. Sanchez, J.K. Baumgardt, S. Kundra*, E.R. Wright, L. Craig and E.H. Egelman (2023). Tad and toxin coregulated pilus structures reveal unexpected diversity in bacterial type IV pili. Proc Nat’l Acad Sci, DOI: 10.1073/pnas.2316668120, PMID 38011558. https://www.pnas.org/doi/10.1073/pnas.2316668120
- View more publications