Cardiovascular and Cerebrovascular Control on Return from ISS (CCISS)
Richard Lee Hughson, Ph.D. (University of Waterloo), J. Kevin Shoemaker, Ph.D., (University of Western Ontario), Andrew Philip Blaber, Ph.D. (Simon Fraser University), Philippe Arbeille, Ph.D., M.D. (University of Tours, France), Danielle Kathleen Greaves, M.Sc. (University of Waterloo).
The ability to maintain arterial blood pressure and brain blood flow immediately on return to Earth after prolonged space flight is one of the most critical factors for crew health and safety. Although the heart rate component of the arterial baroreflex is impaired on return from space, this is not in itself a critical issue as crewmembers who are about to faint normally have markedly elevated heart rate. Rather, their inability to maintain blood pressure appears to be related to inadequate increases in peripheral vascular resistance. This study will incorporate a new methodology that determines the simultaneous gains of the arterial and cardiopulmonary baroreflexes in the control of peripheral vascular resistance.
Publications:
Xu D, Shoemaker JK, Blaber AP, Arbeille P, Fraser K, Hughson RL. (2013) Reduced heart rate variability during sleep in long-duration spaceflight. Am J Physiol Regul Integr Comp Physiol 305(2):R164-70 PMID 23637139
Fraser KS, Greaves DK, Shoemaker JK, Blaber AP, Hughson RL (2012) Heart rate and daily physical activity with long-duration habitation of the international space station. Aviat Space Environ Med, 83(6):577-584. PMID 22764612
Zuj KA, Arbeille P, Shoemaker JK, Blaber AP, Greaves DK, Xu D, Hughson RL (2012) Impaired cerebrovascular autoregulation and reduced CO2 reactivity after long duration spaceflight. Am J Physiol Heart Circ Physiol 302(12): H2592-H2598. (AJP Highlighted article) PMID 22492717
Hughson RL, Shoemaker JK, Blaber AP, Arbeille P, Greaves DK, Pereira-Junior PP, Xu D. (2012) Cardiovascular regulation during long-duration spaceflights to the International Space Station. J Appl Physiol 112( 5):719-727, 2012 PMID 22134699