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Paetzel Lab Structures - by project

Signal peptidase

PDB: 3s04 Crystal structure of Escherichia coli type I signal peptidase in complex with an Arylomycin lipoglycopeptide antibiotic

PDB: 3iiq Crystal structure of Escherichia coli type I signal peptidase in ternary complex with two inhibitors

PDB: 1t7d Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor

PDB: 1kn9 Crystal structure of the Escherichia coli type I signal peptidase apo-enzyme (free active site)

PDB: 1b12 Crystal structure of the Escherichia coli type I signal peptidase in complex with a β-lactam inhibitor

Signal peptide peptidase

PDB: 4kwb Crystal structure of Bacillus subtilis signal peptide peptidase A with C-termini bound in its active-sites.

PDB: 3rst Crystal structure of Bacillus subtilis signal peptide peptidase A.

PDB: 3bf0 Crystal structure of Escherichia coli signal peptide peptidase A - Native SppA crystals

PDB: 3bez Crystal structure of Escherichia coli signal peptide peptidase A - SeMet SppA crystals

Birnavirus VP4 protease

PDB: 4izj Crystal structure of yellowtail ascites virus (YAV) VP4 protease - native active site.

PDB: 4izk Crystal structure of yellowtail ascites virus (YAV) VP4 protease - mutant active site(K674A)

PDB: 3p06 Crystal structure of Tellina virus 1 VP4 protease in the form of an intra-molecular(cis)acyl-enzyme complex

PDB: 2pnl Crystal structure of Infection Pancreatic Necrosis Virus (IPNV) VP4 protease - Triclinic form

PDB: 2pnm Crystal structure of Infection Pancreatic Necrosis Virus (IPNV) VP4 protease - Hexagonal form

PDB: 2gef Crystal structure of Blotched Snakehead Virus (BSNV) VP4 protease

SARS-CoV-2 main protease (Mpro)

PDB: 7khp SARS-CoV-2 main protease - acyl-enzyme complex.

PDB: 7joy SARS-CoV-2 main protease - product-enzyme (C145A) complex.

PDB: 7jp1 SARS-CoV-2 main protease - wild-type enzyme.

PDB: 8DRR C145A SARS-CoV-2 main protease - in complex with the nsp4-nsp5 (C4) cut site sequence.

PDB: 8DRS C145A SARS-CoV-2 main protease - in complex with the nsp6-nsp7 (C6) cut site sequence.

PDB: 8DRT C145A SARS-CoV-2 main protease - in complex with the nsp6-nsp7 (C6) cut site sequence (form 2).

PDB: 8DRU C145A SARS-CoV-2 main protease - in complex with the nsp7-nsp8 (C7) cut site sequence.

PDB: 8DRV C145A SARS-CoV-2 main protease - in complex with the nsp8-nsp9 (C8) cut site sequence.

PDB: 8DRW C145A SARS-CoV-2 main protease - in complex with the nsp9-nsp10 (C9) cut site sequence.

PDB: 8DRX C145A SARS-CoV-2 main protease - in complex with the nsp10-nsp11 (C10) cut site sequence (form 2).

PDB: 8DRY C145A SARS-CoV-2 main protease - in complex with the nsp12-nsp13 (C12) cut site sequence.

PDB: 8DRZ C145A SARS-CoV-2 main protease - in complex with the nsp13-nsp14 (C13) cut site sequence.

PDB: 8DS0 C145A SARS-CoV-2 main protease - in complex with the nsp14-nsp15 (C14) cut site sequence (form 2).

PDB: 8DS1 WT_SARS-CoV-2 main protease - in complex with the nsp12-nsp13 (C12) cut site sequence Acyl-Enzyme.

PDB: 8DS2 WT SARS-CoV-2 main protease - in complex with the nsp13-nsp14 (C13) cut site sequence (form 2).

The BAM complex

PDB: 3tgo Crystal structure of the E. coli BamCD complex

PDB: 3sns Crystal structure of Escherichia coli BamC C-terminal domain in space group H3

PDB: 2kxx NMR structure of Escherichia coli BamE, a lipoprotein component of the β-barrel assembly machinery complex

PDB: 3p1l Crystal structure of Escherichia coli BamB, a lipoprotein component of the β-barrel assembly machinery complex, native crystals

Regulatory domain of human cardiac troponin C

PDB: 4gjg Crystal structure of human cNTnC with cadmium reveals a closed conformation - NIQD mutant

PDB: 4gjf Crystal structure of human cNTnC with cadmium reveals a closed conformation - L29Q mutant

PDB: 4gje Crystal structure of human cNTnC with cadmium reveals a closed conformation - refolded

PDB: 3swb Crystal structure of human cNTnC with cadmium reveals a closed conformation - 1.7 Å resolution SAD structure

PDB: 3sd6 Crystal structure of human cNTnC with cadmium reveals a closed conformation - 1.4 Å resolution

PDB: 3rv5 Crystal structure of human cardiac troponin C regulatory domain (cNTnC) in complex with cadmium and deoxycholic acid

Human Cardiac Myosin Binding Protein C

PDB: 2mq0 NMR structure of cMyBP-C C3 domain WT

PDB: 2mq3 NMR structure of cMyBP-C C3 domain R502W mutant

Bacterial membrane protein assembly facilitator YidC

PDB: 3blc Crystal structure of the Escherichia coli YidC P1 domain

Bacterial (TAT) secretion chaperone DmsD

PDB: 3efp Crystal structure of the Escherichia coli DmsD

PDB: 3u41 Crystal structure of the Escherichia coli DmsD in space group P212121

Bacterial secretion chaperone CsaA

PDB: 2q2i Crystal structure of the Agrobacterium tumefaciens CsaA

PDB: 2q2h Crystal structure of the Agrobacterium tumefaciens CsaA with fused phage-display derived peptide

PDB: 2nzh Crystal structure of the Bacillus subtilis CsaA - tetragonal form

PDB: 2pnm Crystal structure of the Bacillus subtilis CsaA - trigonal form

Industrial enzymes

PDB: 3eqa Crystal structure of the catalytic domain of glucoamylase from Aspergillus niger complexed with tris and glycerol

Phospholipid synthesizing enzymes

PDB: 3hl4 Crystal structure of the mammalian CTP:phosphocholine cytidylyltransferase with bound CDP-choline

LexA protease / UmuD protease

PDB: 1jhc Crystal structure of LexA S119A C-terminal tryptic fragment

PDB: 1jhe Crystal structure of LexA L89P,Q92W,E152A,K156A

PDB: 1jhf Crystal structure of LexA G85D

PDB: 1jhh Crystal structure of LexA S119A

β-lactamases

PDB: 1fof Crystal structure of the class D β-lactamase OXA-10

PDB: 1erm Crystal structure of TEM-1 β-lactamase in complex with a boronic acid inhibitor -1

PDB: 1ero Crystal structure of TEM-1 β-lactamase in complex with a boronic acid inhibitor -2

PDB: 1erq Crystal structure of TEM-1 β-lactamase in complex with a boronic acid inhibitor -3

PDB: 8exp Cryo-EM structure of S. aureus BlaR1 with C2 symmetry

PDB: 8exq Cryo-EM structure of S. aureus BlaR1 with C1 symmetry

PDB: 8exr Cryo-EM structure of S. aureus BlaR1 TM and zinc metalloprotease domain

PDB: 8exs Cryo-EM structure of S. aureus BlaR1 F284A mutant

PDB: 8ext Cryo-EM structure of S. aureus BlaR1 F284A mutant in complex with ampicillin