publications
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2024
Barbelanne M, Lu Y, Kumar K, Zhang X, Li C, Park K, Warner A, Xu XZS, Shaham S and Leroux MR and Carvalho CE* (2023) C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors Sci. rep. 14, 28347. abstract & paper
2023
Reed R^, Park K^, Waddell B, Timbers TA, Li C, Baxi K, Giacomin RM, Leroux MR* and Carvalho CE* (2023) The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia. Sci. rep. 13, 9410. abstract & paper ^co-first authors> *co-corresponding authors
2022
Park K and Leroux MR (2022) Composition, organization and mechanisms of the transition zone, a gate for the cilium. EMBO rep. 23, e55420. abstract & paper
Chrystal PW, Lambacher NJ, Doucette LP, Bellingham J, Schiff ER, Noel NCL, Li C, Tsiropoulou S, Casey GA, Zhai Y, Nadolski NJ, Majumder MH, Tagoe J, D'Esposito F, Cordeiro MF, Downes S, Clayton-Smith J, Ellingford J; Genomics England Research Consortium, Mahroo OA, Hocking JC, Cheetham ME, Webster AR, Jansen G, Blacque OE, Allison WT, Au PYB, MacDonald IM, Arno G, and Leroux MR (2022) The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision. Nat. Commun. 13, 6595 abstract & paper
Park K and Leroux MR (2021) IFT trains overcome an NPHP module barrier at the transition zone. J. Cell Biol. 221, e202112015 abstract & paper
2021
Park K, Li C, Tsiropoulou S, Gonçalves J, Kondratev C, Pelletier L, Blacque OE and Leroux MR (2021) CDKL kinase regulates the length of the ciliary proximal segment. Curr. Biol. 31, 2359-2373. abstract & paper
Li C, Beauregard-Lacroix E, Kondratev C, Rousseau J, Heo AJ, Neas K, Graham BH, Rosenfeld JA, Wagner M, Wenzel M, Mutairi FA, Deiab HA, Gleeson JG, Stanley V, Zaki M, Kwon YT, Leroux MR* and Campeau PM* (2021) The N-end rule pathway ubiquitin ligase UBR7 functions together with UBR5 in the Notch signaling pathway and is involved in a neurodevelopmental syndrome with epilepsy, ptosis and hypothyroidism. Am. J. Hum. Genet. 108, 134-147. abstract & paper *co-corresponding authors
2020
van der Burght SN, Rademakers S, Johnson JL, Li C, Kremers GJ, Houtsmuller AB, Leroux MR and Jansen G (2020) Ciliary Tip Signaling Compartment Is Formed and Maintained by Intraflagellar Transport. Curr. Biol. 30, 4299-4306. abstract & paper
Boycott KM, Campeau PM, Howley HE, Pavlidis P, Rogic S, Oriel C, Berman JN, Hamilton RM, Hicks GG, Lipshitz HD, Masson JY, Shoubridge EA, Junker A, Leroux MR, McMaster CR, Michaud JL, Turvey SE, Dyment D, Innes AM, van Karnebeek CD, Lehman A, Cohn RD, MacDonald IM, Rachubinski RA, Frosk P, Vandersteen A, Wozniak RW, Pena IA, Wen XY, Lacaze-Masmonteil T, Rankin C and Hieter P (2020) The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms. Am. J. Hum. Genet. 106, 143-152. abstract & paper
2019
van Dam TJP, Kennedy J, van der Lee R, de Vrieze E, Wunderlich KA, Rix S, Dougherty GW, Lambacher NJ, Li C, Jensen VL, Leroux MR, Hjeij R, Horn N, Texier Y, Wissinger Y, van Reeuwijk J, Wheway G, Knapp B, Scheel JF, Franco B, Mans DA, van Wijk E, Képès F, Slaats GG, Toedt G, Kremer H, Omran H, Szymanska K, Koutroumpas K, Ueffing M, Nguyen TT, Letteboer SJF, Oud MM, van Beersum SEC, Schmidts M, Beales PL, Lu Q, Giles RH, Szklarczyk R, Russell RB, Gibson TJ, Johnson CA, Blacque OE, Wolfrum U, Boldt K, Roepman R, Hernandez-Hernandez V and Huynen MA (2019) CiliaCarta: An integrated and validated compendium of ciliary genes. PLoS One 14, e0216705. abstract & paper
Loucks CM*, Park K*, Walker DS, McEwan AH, Timbers TA, Ardiel EL, Grundy LJ, Li C, Johnson J-L, Kennedy J, Blacque OE, Schafer W, Rankin CH and Leroux MR (2019) EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling eLIFE 8, e37271. abstract & paper *co-first authors
2018
Jensen VL, Lambacher NJ, Li C, Mohan S, Williams CL, Inglis PN, Yoder BK, Blacque OE and Leroux MR (2018) Role for intraflagellar transport in building a functional transition zone. EMBO Rep. 19, e45862. abstract & paper
Bonnefoy S, Watson CM, Kernohan KD, Lemos M, Hutchinson S, Poulter JA, Crinnion LA, Berry I, Simmonds J, Vasudevan P, O'Callaghan C, Hirst RA, Rutman A, Huang L, Hartley T, Grynspan D, Moya E, Li C, Carr IM, Bonthron DT, Leroux M; Care4Rare Canada Consortium, Boycott KM, Bastin P and Sheridan EG (2018) Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects. Am. J. Hum. Genet. 103, 727-739. abstract & paper
Canning P*, Park K*, Gonçalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN and Leroux MR (2018) CDKL family kinases have evolved distinct structural features and ciliary function. Cell Rep. 22, 885-894. abstract & paper *co-first authors
2017
Jensen VL and Leroux MR (2017) Gates for soluble and membrane proteins, and two trafficking systems (IFT and LIFT), establish a dynamic ciliary signaling compartment. Curr. Opin. Cell Biol. 47, 83-91. abstract & paper
Reiter JF and Leroux MR (2017) Genes and molecular pathways underpinning ciliopathies. Nat. Rev. Mol. Cell Biol. 18, 533-47. abstract & paper
Bruel AL, Franco B, Duffourd Y, ..., Leroux MR, Wallingford JB, Blacque OE, Nachury MV, Attie-Bitach T, Rivière JB, Faivre L, Thauvin-Robinet C (2017) Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes. J. Med. Genet. 54, 371-80. abstract & paper
2016
Jensen VL, Carter S, Sanders AA, Li C, Kennedy J, Timbers TA, Cai J, Scheidel N, Kennedy BN, Morin RD, Leroux MR* and Blacque OE* (2016) Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport. PLoS Genet. 12, e1006469. abstract & paper *co-corresponding authors
Timbers TA, Garland SJ, Mohan S, Flibotte S, Edgley M, Muncaster Q, Au V, Li-Leger E, Rosell FI, Cai J, Rademakers S, Jansen G, Moerman DG and Leroux MR (2016) Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT) PLoS Genet. 12, e1006235 abstract & paper
Loucks CM, Bialas NJ, Dekkers MP, Walker DS, Grundy LJ, Li C, Inglis PN, Kida K, Schafer WR, Blacque OE, Jansen G, and Leroux MR (2016) PACRG, a Protein Linked to Ciliary Motility, Mediates Cellular Signaling. Mol Biol Cell. 27, 2133-2144 abstract & paper
Li C, Jensen VL, Park K, Kennedy J, Garcia-Gonzalo FR, Romani M, De Mori R, Bruel AL, Gaillard D, Doray B, Lopez E, Rivière JB, Faivre L, Thauvin-Robinet C, Reiter JF, Blacque OE, Valente EM and Leroux MR (2016) MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. PLoS Biol. 14, e1002416. abstract & paper
2015
Avidor-Reiss T and Leroux MR (2015) Shared and Distinct Mechanisms of Compartmentalized and Cytosolic Ciliogenesis. Curr. Biol. 25, R1143-50. abstract & paper
Yee LE, Garcia-Gonzalo FR, Bowie RV, Li C, Kennedy JK, Ashrafi K, Blacque OE, Leroux MR and Reiter JF (2015) Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. PLoS Genet. 11, e1005627. abstract & paper
Jensen VL, Li C, Bowie RV, Clarke L, Mohan S, Blacque OE and Leroux MR (2015) Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance. EMBO J. 34, 2537-56. abstract & paper
Reviewed by Faculty of 1000! F1000 link
Roberson EC, Dowdle WE, Ozanturk A, Garcia-Gonzalo FR, Li C, Halbritter J, Elkhartoufi N, Porath JD, Cope H, Ashley-Koch A, Gregory S, Thomas S, Sayer JA, Saunier S, Otto EA, Katsanis N, Davis EE, Attié-Bitach T, Hildebrandt F, Leroux MR and Reiter JF (2015) TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone. J. Cell Biol. 209, 129-142. abstract & paper
2014
Nguyen PA, Liou W, Hall DH and Leroux MR (2014) Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J. Cell Sci. 127, 5317-30. abstract & paper
2013
Sung CH and Leroux MR (2013) The roles of evolutionarily conserved functional modules in cilia-related trafficking. Nat. Cell Biol. 15, 1387-97. abstract & paper
Mohan S, Timbers TA, Kennedy J, Blacque OE and Leroux MR (2013) Striated rootlet and non-filamentous forms of rootletin maintain ciliary function. Curr. Biol. 23, 2016-22. abstract & paper Reviewed by Faculty of 1000! F1000 link
Frédéric MY,* Lundin VF*,Whiteside MD, Cueva JG, Tu DK, Kang SYC, Singh H, Baillie DL, Hutter H, Goodman MB, Brinkman FSL and Leroux MR (2013) Identification of 526 Conserved Metazoan Genetic Innovations Exposes a New Role for Cofactor E-like in Neuronal Microtubule Homeostasis. PLoS Genet. 9, e1003804. abstract & paper
Sörgjerd KM, Zako T, Sakono M, Stirling PC, Leroux MR, Saito T, Nilsson P, Sekimoto M, Saido TC, and Maeda M (2013) Human Prefoldin Inhibits Amyloid-β (Aβ) Fibrillation and Contributes to Formation of Nontoxic Aβ Aggregates. Biochemistry 52, 3532-42 abstract & paper
Heydet D, Chen LX, Larter CZ, Inglis C, Silverman MA, Farrell GC and Leroux MR (2013) A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice. Dev. Neurobiol. 73, 1-13. abstract & paper
2012
Reiter JF, Blacque OE, and Leroux MR (2012) The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization. EMBO Rep. 13, 608-18. abstract & paper
Warburton-Pitt SR, Jauregui AR, Li C, Wang J, Leroux MR and Barr MM (2012) Ciliogenesis in Caenorhabditis elegans requires genetic interactions between ciliary middle segment localized NPHP-2 (inversin) and transition zone-associated proteins. J. Cell Sci. 125, 2592-603. abstract & paper
2011
Huang L*, Szymanska K* Jensen VL*, Janecke AR, Innes M, Davis EE, Frosk P, Li C, Willer JR, Chodirker BN, Greenberg CR, McLeod R, Bernier FP, Chudley AE, Muller T, Shboul M, Logan CV, Loucks CM, Beaulieu CL, Bowie RV, Bell SM, Adkins J, Zuniga FI, Ross KD, Wang J, Ban MR, Becker C, Nurnberg P, Douglas S, Craft CM, Akimenko M-A, Hegele RA, Ober C, Utermann G, Bolz HJ, Bulman DE, Katsanis N, Blacque OE, Doherty D, Parboosingh JS, Leroux MR^, Johnson CA, and Boycott KM (2011) TMEM237 Is Mutated in Individuals with a Joubert Syndrome Related Disorder and Expands the Role of the TMEM Family at the Ciliary Transition Zone. Am. J. Hum. Genet. 89, 713–30. *equal contribution ^co-corresponding authors abstract & paper
Mok CA, Healey MP, Shekhar T, Leroux MR, Héon E, Zhen M (2011) Mutations in a Guanylate Cyclase GCY-35/GCY-36 Modify Bardet-Biedl Syndrome-Associated Phenotypes in Caenorhabditis elegans. PLoS Genet. 7, e1002335. abstract & paper
Phirke P, Efimenko E, Mohan S, Burghoorn J, Crona F, Bakhoum MW, Trieb M, Schuske K, Jorgensen EM, Piasecki BP, Leroux MR and Swoboda P (2011) Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport. Dev. Biol. 357, 235-47. abstract & paper
Williams CL, Li C, Kida K, Inglis PN, Mohan S, Semenec L, Bialas NJ, Stupay RM, Chen N, Blacque OE, Yoder BK and Leroux MR (2011) MKS and NPHP modules cooperate to establish basal body/transition zone-membrane associations and ciliary gate function during ciliogenesis. J. Cell. Biol. 192, 1023-41. abstract & paper Reviewed by Faculty of 1000! F1000 link
2010
Leroux MR (2010) Tubulin acetyltransferase discovered: Ciliary role in the ancestral eukaryote expanded to neurons in metazoans. Proc. Natl. Acad. Sci. USA 107, 21238-9. abstract & paper
Jensen VL, Bialas NJ, Bishop-Hurley SL, Molday LL, Kida K, Nguyen, PA, Blacque OE, Molday RS, Leroux MR and Riddle DL (2010) Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25. PLoS Genet. 6, e1001199. abstract & paper
Johnson JL and Leroux MR (2010) cAMP and cGMP signaling: sensory systems with prokaryotic roots adopted by eukaryotic cilia. Trends in Cell Biol. 20, 435-44. abstract & paper
Wiens CJ, Tong Y, Esmail MA, Oh E, Gerdes JM, Wang J, Tempel W, Rattner JB, Katsanis N, Park HW, and Leroux MR (2010) The Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signalling. J. Biol. Chem. 285, 16218-30. abstract & paper
Lundin VF, Leroux MR and Stirling PC (2010) Quality control of cytoskeletal proteins and human disease. Trends in Biochem. Sci. 35, 288-97. abstract & paper
Quarmby LM and Leroux MR (2010) Sensorium: the original raison d’être of the motile cilium? J. Mol. Cell Biol. 2, 65-67. abstract & paper
2009
Inglis PN, Blacque OE and Leroux MR (2009) Functional genomics of intraflagellar transport-associated proteins in C. elegans. Methods Cell Biol. 93, 267-304.
Lans H, Dekkers MP, Hukema RK, Bialas NJ, Leroux MR and Jansen G (2009) Signaling proteins that regulate NaCL chemotaxis responses modulate longevity in C. elegans. Ann. N. Y. Acad. Sci. 1170, 682-7. abstract & paper
Silverman MA and Leroux MR (2009) Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia. Trends Cell Biol. 19, 306-16. abstract & paper PDF
Bialas NJ^, Inglis PN^, Li C^, Robinson JF, Parker JDK, Healey MP, Davis EE, Inglis CD, Toivonen T, Cottell DC, Blacque OE, Quarmby LM, Katsanis N and Leroux MR (2009) Functional interactions between the ciliopathy-associated Meckel Syndrome 1 (MKS1) protein and two novel MKS1 related (MKSR) proteins. J. Cell Sci. 122, 611-24. ^equal contribution
2008
Dekker C^, Stirling PC^, McCormack EA, Filmore H, Paul A, Brost RL, Costanzo M, Boone C, Leroux MR* and Willison KR* (2008) The interaction network of the chaperonin CCT. EMBO J. 27, 1827-39. *corresponding authors ^equal contribution abstract & paper Reviewed by Faculty of 1000! F1000 link
Li C^, Inglis PN^, Leitch CC, Efimenko E, Zaghoul NA, Mok CA, Davis EE, Bialas NJ, Healey MP, Heon E, Zhen, M, Swoboda P, Katsanis N and Leroux MR (2008) An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes. PLoS Genet. 4, e1000044. ^equal contribution abstract & paper
Lundin VF, Srayko M, Hyman AA and Leroux MR (2008) Eficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans. Dev. Biol. 313, 320-34. abstract & paper
2007
Inglis PN, Ou G, Leroux MR* and Scholey JM (2007) The sensory cilia of Caenorhabditis elegans. Wormbook March 8, p. 1-22. *corresponding author online article and PDF
Tan PL, Barr T, Inglis PN, Mitsuma N, Huang SM, Garcia-Gonzalez MA, Bradley BA, Coforio S, Albrecht PJ, Watnick T, Germino GG, Beales PL, Caterina MJ, Leroux MR, Rice FL and Katsanis N (2007) Loss of Bardet Biedl syndrome proteins causes defects in peripheral sensory innervation and function. Proc. Natl. Acad. Sci. USA 104, 17524-9. abstract & paper
Leroux MR (2007) Taking vesicular transport to the cilium. Cell 129, 1041-3. abstract & paper
Stirling PC, Srayko M, Takhar KS, Pozniakovsky A, Hyman AA and Leroux MR (2007) Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression. Mol. Biol. Cell 18, 2336-45. abstract & paper
Ou G, Koga M, Blacque OE, Murayama T, Ohshima Y, Schafer JC, Li C, Yoder BK, Leroux MR* and Scholey JM* (2007) Sensory ciliogenesis in Caenorhabditis elegans: Assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol. Biol. Cell 18, 1554-69. *corresponding authors abstract & paper
Martin-Benito J, Gomez-Reino J, Stirling PC, Lundin VF, Gomez-Puertas P, Boskovic J, Chacon P, Fernandez JJ, Berenguer J, Leroux MR and Valpuesta JM (2007) Divergent substrate-binding mechanisms reveal an evolutionary specialization of eukaryotic prefoldin compared to its archaeal counterpart. Structure 15, 101-110. abstract & paper
Leroux MR (2007) Role of chaperonin-like proteins in Bardet-Biedl syndrome. Biomedical & Life Sciences Collection, Henry Stewart talks. Video link
2006
Chen N, Mah A, Blacque OE, Chu J, Phgora K, Bakhoum MW, Newbury RH, Khattra J, Chan S, Go A, Efimenko E, Johnsen R, Phirke P, Swoboda P, Marra M, Moerman DG, Leroux MR, Baillie DL and Stein LD (2006) Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics. Genome Biol. 7, R126. abstract & paper PDF
Stirling PC, Bakhoum SF, Feigl AB and Leroux MR (2006) Convergent evolution of clamp-like binding sites inn diverse chaperones. Nat. Struct. Mol. Biol. 13, 865-870. abstract & paper PDF
Blacque OE, Li C, Inglis PN, Esmail MA, Ou G, Mah AK, Baillie DL, Scholey JM and Leroux MR (2006) The WD repeat-containing protein, IFTA-1, is required for retrograde intraflagellar transport. Mol. Biol. Cell 17, 5053-62. abstract & paper PDF
Pan X, Ou G, Civelekoglu-Scholey G, Blacque OE, Endres NF, Tao L, Mogilner A, Leroux MR, Vale RD and Scholey JM (2006) Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. J. Cell Biol. 174, 1035-45. abstract & paper PDF Reviewed by Faculty of 1000! F1000 link
Efimenko E, Blacque OE, Ou G, Haycraft CJ, Yoder BK, Scholey JM, Leroux MR and Swoboda P (2006) Caenorhabditis elegans DYF-2, an ortholog of human WDR19, is a component of the IFT machinery in sensory cilia. Mol. Biol. Cell 17, 4801-11. abstract & paper PDF
Blacque OE and Leroux MR (2006) Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport Cell. Mol. Life Sci. 63, 2145-61. abstract & paper PDF
Inglis PN, Boroevich KA, and Leroux MR (2006) Piecing together a ciliome. Trends Genet. 22, 491-500. abstract & paper PDF
Sayer JA, Otto EA, O'Toole JF, Nurnberg G, Kennedy MA, ..., Leroux MR and Friedhelm H (2006) The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat. Genet. 38, 674-681. abstract & paper Reviewed by Faculty of 1000! F1000 link
Stirling PC, Cuellar J, Alfaro GA, Khadali FE, Beh CT, Valpuesta JM, Melki R, and Leroux MR (2006) PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates. J. Biol. Chem. 281, 7012-7021. abstract & paper
2005
Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR, Henderson DJ, Murdoch JN, Copp AJ, Eliot MM, Lupski JR, Kemp DT, Dollfus H, Tada M, Katsanis N, Forge A and Beales PL (2005) Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat. Genet. 37, 1135-1140. abstract & paper PDF Reviewed by Faculty of 1000! F1000 link
Ou G, Blacque OE, Snow JJ, Leroux MR and Scholey JM (2005) Functional coordination of intraflagellar transport motors. Nature 436, 583-587. abstract & paper
Blacque OE, Perens EA, Boroevich KA, Inglis PN, Li C, Warner A, Khattra J, Holt RA, Ou G, Mah AK, McKay SJ, Huang P, Swoboda P, Jones SJ, Marra MA, Baillie DL, Moerman DG, Shaham S and Leroux MR (2005) Functional genomics of the cilium, a sensory organelle. Curr. Biol. 15, 935-941. abstract & paper
Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH and Swoboda P (2005) Analysis of xbx genes in C. elegans. Development 132, 1923-1934. abstract & paper
Kim JC, Ou YY, Badano JL, Esmail MA, Leitch CC, Fiedrich E, Beales PL, Archibald JM, Katsanis N, Rattner JB and Leroux MR (2005) MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis. J. Cell Sci. 118, 1007-20. abstract & paper
2004
Fan Y, Esmail MA, Ansley SJ, Blacque OE, Boroevich K, Ross AJ, Moore SJ, Badano JL, May-Simera H, Compton DS, Green JS, Lewis RA, van Haelst MM, Parfrey PS, Baillie DL, Beales PL, Katsanis N, Davidson WS and Leroux MR (2004) Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome. Nat. Genet. 36, 989-93. abstract & paper
Blacque OE, Reardon MJ, Li C, McCarthy J, Mahjoub MR, Ansley SJ, Badano JL, Mah AK, Beales PL, Davidson WS, Johnsen RC, Audeh M, Plasterk RH, Baillie DL, Katsanis N, Quarmby LM, Wicks SR and Leroux MR (2004) Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev. 18, 1630-42. abstract & paper Reviewed by Faculty of 1000! F1000 link
Okochi M, Nomura T, Zako T, Arakawa T, Iizuka R, Ueda H, Funatsu T, Leroux M and Yohda M (2004) Kinetics and binding sites for interaction of the prefoldin with a group II chaperonin: contiguous non-native substrate and chaperonin binding sites in the archaeal prefoldin. J. Biol. Chem. 279, 31788-95. abstract & paper
Li JB, Gerdes JM, Haycraft CJ, Fan Y, Teslovich TM, May-Simera H, Li H, Blacque OE, Li L, Leitch CC, Lewis RA, Green JS, Parfrey PS, Leroux MR, Davidson WS, Beales PL, Guay-Woodford LM, Yoder BK, Stormo GD, Katsanis N and Dutcher SK (2004) Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell 117, 541-52. abstract & paper Reviewed by Faculty of 1000! F1000 link
Kim JC, Badano JL, Sibold S, Esmail MA, Hill J, Hoskins BE, Leitch CC, Venner K, Ansley SJ, Ross AJ, Leroux MR*, Katsanis N* and Beales PL (2004) The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat. Genet. 36, 462-70. *corresponding authors abstract & paper Reviewed by Faculty of 1000! F1000 link
Lundin VF, Stirling PC, Gomez-Reino J, Mwenifumbo JC, Obst JM, Valpuesta JM and Leroux MR (2004) Molecular clamp mechanism of substrate binding by hydrophobic coiled-coil residues of the archaeal chaperone prefoldin. Proc. Natl. Acad. Sci. USA 101, 4367-72. abstract & paper Reviewed by Faculty of 1000! F1000 link
2003
Ansley SJ, Badano JL, Blacque OE, Hill J, Hoskins BE, Leitch CC, Kim JC, Ross AJ, Eichers ER, Teslovich TM, Mah AK, Johnsen RC, Cavender JC, Lewis RA, Leroux MR*, Beales PL* and Katsanis N* (2003) Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 425, 628-33. *equal lab contribution abstract & paper PDF Reviewed by Faculty of 1000! F1000 link
Badano JL, Kim JC, Hoskins BE, Lewis RA, Ansley SJ, Cutler DJ, Castellan C, Beales PL, Leroux MR and Katsanis N (2003) Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus. Hum. Mol. Genet. 12, 1651-9. abstract & paper
Stirling PC, Lundin VF and Leroux MR (2003) Getting a grip on non-native proteins. EMBO Rep. 4, 565-70. abstract & paper
2000-2001
Leroux MR (2001) Protein folding and molecular chaperones in archaea. Adv. Appl. Microbiol. 50, 219-77. abstract & paper
Leroux MR (2000) Analysis of eukaryotic molecular chaperone complexes involved in actin folding. Methods Mol. Biol. 140, 195-206. abstract & paper
Leroux MR and Hartl FU (2000) Cellular functions of molecular chaperones. In: Frontiers in Molecular Biology. Mechanisms of protein folding (ed. Pain R), 2nd edition, Oxford University Press, Oxford.
Leroux MR and Hartl FU (2000) Protein folding: versatility of the cytosolic chaperonin TRiC/CCT. Curr. Biol. 10, R260-4. abstract & paper
Siegert R*, Leroux MR*, Scheufler C, Hartl FU and Moarefi I (2000) Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins. Cell 103, 621-32. *equal contribution abstract & paper
Fandrich M, Tito MA, Leroux MR, Rostom AA, Hartl FU, Dobson CM and Robinson CV (2000) Observation of the noncovalent assembly and disassembly pathways of the chaperone complex MtGimC by mass spectrometry. Proc. Natl. Acad. Sci. USA 97, 14151-5. abstract & paper
1999
Leroux MR, Fandrich M, Klunker D, Siegers K, Lupas AN, Brown JR, Schiebel E, Dobson CM and Hartl FU (1999) MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin. EMBO J. 18, 6730-43. abstract & paper
Siegers K, Waldmann T, Leroux MR, Grein K, Shevchenko A, Schiebel E and Hartl FU (1999) Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system. EMBO J. 18, 75-84. abstract & paper
1995-1998
Kokke BP, Leroux MR, Candido EP, Boelens WC de Jong WW (1998) Caenorhabditis elegans small heat-shock proteins Hsp12.2 and Hsp12.3 form tetramers and have no chaperone-like activity. FEBS Lett. 433, 228-32. abstract & paper
Leroux MR and Candido EP (1997) Subunit characterization of the Caenorhabditis elegans chaperonin containing TCP-1 and expression pattern of the gene encoding CCT-1. Biochem. Biophys. Res. Commun. 241, 687-92. abstract & paper
Leroux MR, Melki R, Gordon B, Batelier G and Candido EP (1997) Structure-function studies on small heat shock protein oligomeric assembly and interaction with unfolded polypeptides. J. Biol. Chem. 272, 24646-56. abstract & paper
Leroux MR, Ma BJ, Batelier G, Melki R and Candido EP (1997) Unique structural features of a novel class of small heat shock proteins. J. Biol. Chem. 272, 12847-53. abstract & paper
Leroux MR and Candido EP (1995) Characterization of four new tcp-1-related cct genes from the nematode Caenorhabditis elegans. DNA Cell Biol. 14, 951-60. abstract & paper
Leroux MR and Candido EP (1995) Molecular analysis of Caenorhabditis elegans tcp-1, a gene encoding a chaperonin protein. Gene 156, 241-6. abstract & paper
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