Course Description:

This course will emphasize the adverse effects of environmental chemicals on mammalian species. Students who plan to choose environmental toxicology as a career or to write the Diplomat of American Board of Toxicology examination will find the following topics very useful.

Lecture Topics:

PART I - GENERAL PRINCIPLES OF TOXICOLOGY
 

- Introduction to toxicology.
- Absorption, distribution and excretion of toxicants
- Biotransformation of toxicants
- Toxicokinetics
- Toxic effects
- Factors influencing toxicity and selective toxicity

- The lungs
- The blood
- The nervous system
- The skin
- The kidneys
- The liver

PART III - TESTING PROCEDURES AND RISK ASSESSMENT
 

- Acute, short-term and long-term toxicity studies
- Chemical carcinogenesis
- Chemical mutagenesis and teratogenesis
- Other testing procedures including genetic toxicology
- Human health risk assessment

PART IV - TOXICANTS
 

- Heavy metals and antogonists
- Pesticides
- Chlorinated aromatic hydrocarbons and related chemicals
- Food additives and contaminants
- Natural toxins
- Endocrine disrupting chemicals

Course Text: Basic Toxicology, Third Edition, Frank C. Lu. ISN 1-56032-380-9. Taylor and Francis

Mark Breakdown:
 

MIDTERM          30%
FINAL                 55%
TUTORIAL        15%
TOTAL               100%