Jack Chen, Associate Professor

Department of Molecular Biology and Biochemistry
Simon Fraser University

Office: SSB8111
Phone: (778)782-4823
Email: chenn(at)sfu.ca

B.Sc., Fudan University, Shanghai
Ph.D., Chinese Academy of Sciences, Qingdao

Operon

REVIEWS & BACKGROUND

Trans-splicing and operons(Blumenthal, WormBook, 2005)
Operons in eukaryotes (Blumenthal, Briefings in Functional Genomics and Proteomics, 2004)
Caenorhabditis elegans operons: form and function (Blumenthal and Gleason, Nature Reviews Genetics, 2003)
Widespread organisation of C. elegans genes into operons: Fact or function? (Nimmo and Woollard, BioAssays, 2002)

METHDOS & DISCOVERY

Caenorhabditis elegans Operons Contain a Higher Proportion of Genes with Multiple Transcripts and Use 3' Splice Sites Differentially (Wang et al., PLoS ONE, 2010)
SL2-like spliced leader RNAs in the basal nematode Prionchulus punctatus: New insight into the evolution of nematode SL2 RNAs(Harrison et al., RNA, 2010)
The Evolutionary Dynamics of Operon Distributions in Eukaryote Genomes (Cutter and Agrawal, Genetics, 2010)
Regulation of transcription termination in the nematode Caenorhabditis elegans(Haenni et al., NAR, 2010)
Comparative Functional Analysis of the Caenorhabditis elegans and Drosophila melanogaster Proteomes(Schrimpf et al., PLoS Biology, 2010)
Note: This study can reveal the "real" start of proteins in C. elegans, which can be used to compare with the start codons of predicted gene models.
Germline Expression Influences Operon Organization in the Caenorhabditis elegans Genome(Reinke and Currer, Genetics, 2010)
Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen(Cui et al., PNAS, 2008)
Evolutionary dynamics of nematode operons: Easy come, slow go(Qian and Zhang, Genome Research, 2008)
Identification and analysis of internal promoters in Caenorhabditis elegans operons(Huang et al., Genome Research, 2007)
C. elegans sequences that control trans-splicing and operon pre-mRNA processing (Graber et al., RNA, 2007
On the Paucity of Duplicated Genes in Caenorhabditis elegans Operons (Gavalcanti et al., Journal of Molecular Evolution, 2006)
Eukaryotic Operon Genes Can Define Highly Conserved Syntenies (Trachtulec, Folia Biol, 2004)
Genome annotation by high-throughput 5' RNA end determination (Hwang et al., PNAS, 2004)
The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics (Stein et al., PLoS Biology, 2003)
A New Gene-finding Tool USING THE CAENORHABDITIS ELEGANS OPERONS FOR IDENTIFYING FUNCTIONAL PARTNER PROTEINS IN HUMAN CELLS (Eichmuller et al., JBC, 2003)
Operon Structure and Trans-Splicing in the Nematode Pristionchus pacificus (Lee and Sommer, Molecular Biology and Evolution, 2003)
An uncapped RNA suggests a model for Caenorhabditis elegans polycistronic pre-mRNA processing (Liu et al., RNA, 2003)
A global analysis of Caenorhabditis elegans operons (Blumenthal et al., Nature, 2002)

Operons in eukaryotes other than C. elegans

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Jack Chen, Associate Professor

Department of Molecular Biology and Biochemistry Simon Fraser University

Operon

REVIEWS & BACKGROUND

METHDOS & DISCOVERY

Operons in eukaryotes other than C. elegans

Department of Molecular Biology and Biochemistry
Simon Fraser University