Jack Chen, Associate Professor
Department of Molecular Biology and Biochemistry
Simon Fraser University
Office:
SSB8111
Phone:
(778)782-4823
Email:
chenn(at)sfu.ca
B.Sc.,
Fudan University, Shanghai
Ph.D.,
Chinese Academy of Sciences, Qingdao
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Publications
REVIEWS
The Molecular Basis of Organ Formation: Insights From the C. elegans Foregut (Mango, Annual Reviews in Cell and Developmental Biology, 2009)
In the Beginning Was the Worm . . . (Brenner, Genetics, 2009)
Finding function in novel targets: C. elegans as a model organism (Kaletta and Hengartner, Nature Reviewers Drug Discovery, 2006)
The art and design of genetic screens: Caenorhabditis elegans (Jorgensen and Mango, Nature Reviewers Genetics, 2002)
CLASSICAL GENETIC SCREENINGS
Mutations affecting the chemosensory neurons of Caenorhabditis elegans. (Starich et al., Genetics, 1995)
Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans (Ferguson and Horvitz, Genetics, 1985)
Egg-laying defective mutants of the nematode Caenorhabditis elegans (Trent, Tsung, and Horvitz, Genetics, 1983)
Male phenotypes and mating efficiency in Caenorhabditis elegans (Hodgkin, Genetics, 1983)
Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans (Horvitz and Sulston, Genetics, 1980)
Osmotic avoidance defective mutants of the nematode Caenorhabditis elegans (Culotti and Russel, Genetics, 1978)
Specific neuroanatomical changes in chemosensory mutants of the nematode Caenorhabditis elegans (Lewis and Hodgkin, Journal of Comparative Neurology, 1977)
Chemotaxis-defective mutants of the nematode Caenorhabditis elegans (Dusenbery, Sheridan, and Russel, Genetics, 1975)
Normal and mutant thermotaxis in the nematode Caenorhabditis elegans. (Hedgecock and Russell, Genetics, 1975)
The genetics of Caenorhabditis elegans (Brenner, Genetics, 1974)
Chemotaxis by the Nematode Caenorhabditis elegans: Identification of Attractants and Analysis of the Response by Use of Mutants (Ward, PNAS, 1973)
GFP AS MARKER
The WD40 Repeat PtdIns(3)P-Binding Protein EPG-6 Regulates Progression of Omegasomes to Autophagosomes (Lu et al., Developmental Cell, 2011)
Note:
This study screened ~10,000 genomes and identified 68 mutants.
The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons.
(Lesch and Bargmann, Genes & Development, 2010)
The HMX/NKX homeodomain protein MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene in C. elegans
(Kim et al., Development, 2010)
Polycomb-like genes are necessary for specification of dopaminergic and serotonergic neurons in Caenorhabditis elegans. (Yang et al., PNAS, 2007)
Otx/otd Homeobox Genes Specify Distinct Sensory Neuron Identities in C. elegans
(Lanjuin et al., Developmental Cell, 2003)
Regulation of Chemosensory Receptor Expression and Sensory Signaling by the KIN-29 Ser/Thr Kinase (Lanjuin and Sengupta, Neuron, 2002)
Note:
This study screens ~8000 haploid genomes for mutations that cause reduction or loss of expression of str-1::GFP. Two alleles affecting kin-29 were found.
Specification of Thermosensory Neuron Fate in C. elegans Requires ttx-1, a Homolog of otd/Otx (Satterlee et al., Neuron, 2001)
The SAD-1 Kinase Regulates Presynaptic Vesicle Clustering and Axon Termination (Crump et al., Neuron, 2001)
Regulation of endocytosis by CUP-5, the Caenorhabditis elegans mucolipin-1 homolog (Fares and Greenwald, Nature Genetics, 2001)
Genetic Analysis of Endocytosis in Caenorhabditis elegans: Coelomocyte Uptake Defective Mutants (Fares and Greenwald, Genetics, 2001)
Regulation of Presynaptic Terminal Organization by C. elegans RPM-1, a Putative Guanine Nucleotide Exchanger with a RING-H2 Finger Domain (Zhen et al., Neuron, 2000)
rpm-1, A Conserved Neuronal Gene that Regulates Targeting and Synaptogenesis in C. elegans (Schaefer et al., Neuron, 2000)
Visualization of synaptic specializations in live C. elegans with synaptic vesicle protein-GFP fusions (Nonet, Journal of Neuroscience Methods, 1999)
The RING finger/B-Box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans (Hsieh et al., Genes & Dev, 1999)
Receptor-mediated Endocytosis in the Caenorhabditis elegans Oocyte (Grant et al., MBoC, 1999)
Lateral Signaling Mediated by Axon Contact and Calcium Entry Regulates Asymmetric Odorant Receptor Expression in C. elegans (Troemel et al., Cell, 1999)
The Conserved Immunoglobulin Superfamily Member SAX-3/Robo Directs Multiple Aspects of Axon Guidance in C. elegans (Zallen et al., Cell, 1998)
Identification of Heterochronic Mutants in Caenorhabditis elegans: Temporal Misexpression of a Collagen::Green Fluorescent Protein Fusion Gene (Abrahante et al., Genetics, 1998)