Jack Chen, Associate Professor
Department of Molecular Biology and Biochemistry
Simon Fraser University
Office:
SSB8111
Phone:
(778)782-4823
Email:
chenn(at)sfu.ca
B.Sc.,
Fudan University, Shanghai
Ph.D.,
Chinese Academy of Sciences, Qingdao
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REVIEWS
Maintaining a memory by transcriptional autoregulation (Hobert, Current Biology, 2011)
Transcriptional Control of the Terminal Fate of Monoaminergic Neurons (Flames and Hobert, Annual Reviews of Neuroscience, 2011)
Gene-centered regulatory networks (Arda and Walhout, Brif Func Genomics, 2010)
Gene Regulation: Enhancers Stepping Out of the Shadow (Hobert, Current Biology, 2010)
Lineage programming: navigating through transient regulatory states via binary decisions (Bertrand and Hobert, Current Opinion in Genetics and Develoment, 2010)
Comparative genomics of gene conservation and divergence of cis-regulatory information (Meireles-Filho and Stark, Current Opinion in Genetics and Development, 2009)
Germ Versus Soma Decisions: Lessons from Flies and Worms (Strome and Lehmann, Science, 2007)
Transcriptional regulation (Okkema and Karause, WormBook, 2005)
Research articles
A Left/Right Asymmetric Neuronal Differentiation Program Is Controlled by the Caenorhabditis elegans LSY-27 Zinc-Finger Transcription Factor (Zhang et al., Genetics, 2011)
Using a structural and logics systems approach to infer bHLHDNA binding specificity determinants (De Masi et al., Nucleic Acids Research, 2011)
The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons (Lesch and Bargmann, Genes and Development, 2010)
The HMX/NKX homeodomain protein MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene in C. elegans (Kim, Kim, and Sengupta, Development, 2010)
Conserved elements associated with ribosomal genes and their trans-splice acceptor sites in Caenorhabditis elegans (Sleumer et al., Nucleic Acids Research, 2010)
A Multiparameter Network Reveals Extensive Divergence between C. elegans bHLH Transcription Factors (Grove et al., Cell, 2009)
The C. elegans Tailless/TLX transcription factor nhr-67 controls neuronal identity and left/right asymmetric fate diversification (Sarin et al., Development, 2009)
The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis (Kato and Sternberg, Development, 2009)
Multigenome DNA sequence conservation identifies Hox cis-regulatory elements (Kuntz et al., Genome Research, 2008)
Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity (Martinez et al., Genome Research, 2008)
KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC (van der Linden et al., EMBO J, 2007)
Identification of muscle-specific regulatory modules in Caenorhabditis elegans (Zhao et al., Genome Research, 2007)
Multiple regulatory elements with spatially and temporally distinct activities control the expression of the epithelial differentiation gene lin-26 in C. elegans (Landmann et al., Developmental Biology, 2004)
The Divergent Orphan Nuclear Receptor ODR-7 Regulates Olfactory Neuron Gene Expression via Multiple Mechanisms in Caenorhabditis elegans (Colosimo et al., Genetics, 2003)