Nature has evolved complex mechanisms to ensure the directed transport and stable positioning of intracellular components despite the random thermal fluctuations that are important at microscopic length scales. These mechanisms have inspired several synthetic (mostly DNA based) motors with high levels of programmability which can be tuned to explore the mechanochemical principles that guide directional motion. Recently, an autonomous, highly polyvalent DNA monowheel which cleaves a complementary RNA substrate has recorded higher forces and velocities than previous synthetic DNA-based motors. In this talk I will first present a coarse-grained model for a highly polyvalent rotational monowheel which is capable of translocating via both, translation and rotation. We will discuss the operational principles underlying the dynamics of the motor as a function of the motor size, the chemical kinetics of the motor-substrate interaction, and interaction strength. Finally, we will discuss how the collective action of multiple microscopic interactions at the motor-substrate interface leads to distinct motility modes for the motor within particular parameter regimes for this system.